Apparent diffusion coefficient predicts biochemical response in neuroendocrine liver metastases treated using targeted radiolabelled therapy
نویسندگان
چکیده
Introduction: Y-DOTATyr3octreotide (Y-DOTATOC) therapy targets tumour cells expressing somatostatin receptors and induces tumour apoptosis and necrosis. However, assessment of treatment response using conventional imaging criteria is unreliable because treatment may induce disease stabilization rather than disease regression, and disease can also be slow to regress despite clinical benefits [1]. The apparent diffusion coefficient (ADC) derived by diffusion-weighted MR imaging (DW-MRI) is being evaluated as a biomarker for tumour response to anti-cancer treatment. Tumour ADC is expected to increase as a result of tissue apoptosis or necrosis. However, the value of DW-MRI for assessing the treatment effects of Y-DOTATOC treatment, in patients with neuroendocrine liver metastases is unknown.
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